Monthly haemostatic factor variability in women and men.

Pubmed ID: 24382103

Pubmed Central ID: PMC4153833

Journal: European journal of clinical investigation

Publication Date: Jan. 1, 2014

MeSH Terms: Humans, Male, Adult, Female, Aged, Middle Aged, Sex Factors, Young Adult, Linear Models, Postmenopause, Fibrinogen, Premenopause, Progesterone, Plasminogen Activator Inhibitor 1, Factor VII, Estradiol, Luteinizing Hormone, Menstrual Cycle, Periodicity

Grants: M01 RR000645, M01-NCRR 00645, U01 HL049649, U01 HL049644, U01 HL049659, U01 HL049648, U01 HL049651, 5-U01-HL 049644

Authors: Tracy RP, Tracy RP, Jacobs DR, Folsom AR, Rodriguez C, Johnson C, Ginsberg HN, Ginsberg HN, Anderson N, Jones J, Proschan M, Martin L, Williams B, Ramakrishnan R, Cornell E, Davis C, Jonnalagadda SS, Smiciklas-Wright H, Karmally W, Ershow AG, Ershow AG, Kris-Etherton PM, Berglund L, Lefevre M, Lefevre M, Elmer PJ, Elmer PJ, Stewart PW, Stewart PW, Pearson TA, Pearson TA, Dennis BH, Phillips KM, Farhat-Wood A, Kris-Etherton P, Roheim P, Stewart KK, Holleran S, Holleran S, Hill AM, Fung MK, Reed RG, Reed RG, Siddiqui M, Chen NT, Holeman R, Chirgwin K, Stennett K, Ganga L, Towolawai TT, Myers M, Ngai C, Fontenez N, Useche N, Ryan D, Windhauser MM, Champagne CM, Williamson D, Tulley R, Brock R, Bodin D, Kennedy B, Barkate M, Foust E, York D, Derr J, Mustad VA, Meaker K, Mills E, Tilley MA, Sigman-Grant M, Xavier-Guinard J, Sechevich P, Reddy C, Mastro AM, Cooper A, Van Heel NM, Wold AC, Fritz L, Slavin JL, Davis CE, Hosking J, Blackwell SE, Bryan H, Stewart W, Abolafia J, Foley M, Zien C, Leu SY, Youngblood M, Goodwin T, Miles M, Wehbie J, McGee BB, Beecher GR, Holden JM, Gordon DJ, Rifkind B

Cite As: Hill AM, Stewart PW, Fung MK, Kris-Etherton PM, Ginsberg HN, Tracy RP, Pearson TA, Lefevre M, Reed RG, Elmer PJ, Holleran S, Ershow AG, Dietary Effects on Lipoproteins and Thrombogenic Activity Investigators. Monthly haemostatic factor variability in women and men. Eur J Clin Invest 2014;44(3):309-18.

Studies:

Abstract

BACKGROUND: Hormonal status influences haemostatic factors including fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), and concentrations differ among men, premenopausal and postmenopausal women. This study examines how phases of the menstrual cycle influence variability of fibrinogen, factor VII and PAI-1. DESIGN: We studied 103 subjects (39 premenopausal women, 18 postmenopausal women and 46 men) during three, randomized, 8-week energy- and nutrient-controlled experimental diets in the Dietary Effects on Lipids and Thrombogenic Activity (DELTA) Study. Fasting blood samples were collected weekly during the last 4 weeks of each diet period, and haemostatic factors were quantified. Two linear mixed-effects models were used for fibrinogen, factor VII and PAI-1: one to estimate and compare group-specific components of variance, and the other to estimate additional fixed effects representing cyclical functions of day of menstrual cycle in premenopausal women. RESULTS: Systematic cyclical variation with day of menstrual cycle was observed for fibrinogen (P < 0.0001), factor VII (P = 0.0012) and PAI-1 (P = 0.0024) in premenopausal women. However, the amplitude of cycling was small relative to the total magnitude of intra-individual variability. In addition, the intra-individual variance and corresponding coefficient of variation observed in premenopausal women did not differ from postmenopausal women and men. CONCLUSIONS: The variability in haemostatic factors in premenopausal women is no greater than for postmenopausal women or men. Consequently, premenopausal women can be included in studies investigating haemostatic factor responses without controlling for stage of menstrual cycle.