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A combination of mild-moderate hypoxemia and low compliance is highly prevalent in persistent ARDS: a retrospective study.
Pubmed ID: 38173002
Pubmed Central ID: PMC10765810
Journal: Respiratory research
Publication Date: Jan. 3, 2024
Affiliation: Department of Intensive Care, University Hospital of Heraklion, University of Crete School of Medicine, Voutes Campus, Office 8A4, Heraklion, Crete, 70013, Greece. vaporidi@uoc.gr.
MeSH Terms: Humans, Lung, Retrospective Studies, Respiration, Artificial, Hypoxia, COVID-19, Respiratory Distress Syndrome
Grants: 80- 1/15.10.2020
Authors: Siempos II, Papoutsi E, Vaporidi K, Andrianopoulos I, Papathanakos G, Koulouras V, Mavrikaki V, Bolaki M, Stamatopoulou V, Toli E, Kondili E
Cite As: Papoutsi E, Andrianopoulos I, Mavrikaki V, Bolaki M, Stamatopoulou V, Toli E, Papathanakos G, Koulouras V, Kondili E, Siempos II, Vaporidi K. A combination of mild-moderate hypoxemia and low compliance is highly prevalent in persistent ARDS: a retrospective study. Respir Res 2024 Jan 3;25(1):1.
Studies:
- Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA)
- Acute Respiratory Distress Network (ARDSNet) Studies 07, 08, 09, 11, and 12 Early Versus Delayed Enteral Feeding to Treat People with Acute Lung Injury or Acute Respiratory Distress Syndrome (EDEN)
- Acute Respiratory Distress Network (ARDSNet) Studies 10 and 12 Statins for Acutely Injured Lungs from Sepsis (SAILS)
- Acute Respiratory Distress Network (ARDSNet) Study 05 Fluid and Catheter Treatment Trial (FACTT)
Abstract
BACKGROUND: The Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and edema, impairing both oxygenation and lung compliance. Recent studies reported a dissociation between oxygenation and compliance (severe hypoxemia with preserved compliance) in early ARDS and COVID-19-related-ARDS (CARDS). During the pandemic, in patients requiring prolonged mechanical ventilation, we observed the opposite combination (mild-moderate hypoxemia but significantly impaired compliance). The purpose of our study was to investigate the prevalence of this combination of mild-moderate hypoxemia and impaired compliance in persistent ARDS and CARDS. METHODS: For this retrospective study, we used individual patient-level data from two independent cohorts of ARDS patients. The ARDSNet cohort included patients from four ARDS Network randomized controlled trials. The CARDS cohort included patients with ARDS due to COVID-19 hospitalized in two intensive care units in Greece. We used a threshold of 150 for PaO<sub>2</sub>/FiO<sub>2</sub> and 30 ml/cmH<sub>2</sub>O for compliance, estimated the prevalence of each of the four combinations of oxygenation and compliance at baseline, and examined the change in its prevalence from baseline to day 21 in the ARDSNet and CARDS cohorts. RESULTS: The ARDSNet cohort included 2909 patients and the CARDS cohort included 349 patients. The prevalence of the combination of mild-moderate hypoxemia and low compliance increased from baseline to day 21 both in the ARDSNet cohort (from 22.2 to 42.7%) and in the CARDS cohort (from 3.1 to 33.3%). Among surviving patients with low compliance, oxygenation improved over time. The 60-day mortality rate was higher for patients who had mild-moderate hypoxemia and low compliance on day 21 (28% and 56% in ARDSNet and CARDS), compared to those who had mild-moderate hypoxemia and high compliance (20% and 50%, respectively). CONCLUSIONS: Among patients with ARDS who require prolonged controlled mechanical ventilation, regardless of ARDS etiology, a dissociation between oxygenation and compliance characterized by mild-moderate hypoxemia but low compliance becomes increasingly prevalent. The findings of this study highlight the importance of monitoring mechanics in patients with persistent ARDS.