Ancestry of African Americans with sickle cell disease.

Pubmed ID: 21546286

Pubmed Central ID: PMC3116635

Journal: Blood cells, molecules & diseases

Publication Date: June 15, 2011

Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. ntimofee@bu.edu

MeSH Terms: Humans, Polymorphism, Single Nucleotide, Anemia, Sickle Cell, Genome-Wide Association Study, Cluster Analysis, Databases, Genetic, Ethnicity, Black or African American

Grants: R01 AG009029, R01 AG009029-09, R01 AG025259, R01 AG025259-01A2, R01 AG09029, R01 HL 068970, R01 HL 87681, R01 HL068970-01, R01 HL087681-01, ZIA HL006012-01, ZIA HL006012-02, R01 HL068970, R01 HL087681

Authors: Sebastiani P, Solovieff N, Hartley SW, Gladwin MT, Baldwin CT, Steinberg MH, Klings ES, Taylor JG, Kato GJ, Farrer LA

Cite As: Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor JG 6th, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P. Ancestry of African Americans with sickle cell disease. Blood Cells Mol Dis 2011 Jun 15;47(1):41-5. Epub 2011 May 4.

Studies:

Abstract

The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.