Non-A, non-B hepatitis transmission in chimpanzees: a project of the transfusion-transmitted viruses study group.

Pubmed ID: 632054

Journal: Intervirology

Publication Date: Jan. 1, 1978

MeSH Terms: Humans, Male, Female, Animals, Antibodies, Viral, Hepatitis, Viral, Human, Alanine Transaminase, Aspartate Aminotransferases, Pan troglodytes, Transfusion Reaction

Authors: Mosley JW, Aach RD, Hollinger FB, Stevens CE, Gitnick GL, Szmuness W, Peters RL, Weiner JM, Werch JB, Lander JJ

Cite As: Hollinger FB, Gitnick GL, Aach RD, Szmuness W, Mosley JW, Stevens CE, Peters RL, Weiner JM, Werch JB, Lander JJ. Non-A, non-B hepatitis transmission in chimpanzees: a project of the transfusion-transmitted viruses study group. Intervirology 1978;10(1):60-8.

Studies:

Abstract

Experimental transmission of non-A, non-B hepatitis was apparently accomplished in 5 chimpanzees following inoculation with presumably infectious human sera. Administration of sera from implicated donors with normal alanine aminotransferase (ALT) values, as well as from those with abnormal ALT levels, resulted in the development of ALT abnormalities in the inoculated chimpanzees. Transmission from donors with normal ALT values implies that healthy carriers of non-A, non-B virus exist. Evidence is presented which indicates that a period of viremia precedes the clinical illness by at least 12 days.