Transfusion-Transmitted Viruses Study (TTVS) - Catalog

  • Name

    Transfusion-Transmitted Viruses Study (TTVS)

  • Accession Number

    HLB01910909a

  • Acronym

    TTVS

  • Related studies
    (NANB-TAH) Natural History Study of Non-A, Non-B Post-Transfusion Hepatitis (NANB-TAH)
  • BSI Study IDs

    TTV

  • Is public use dataset

    False

  • Keywords
  • Ingestion Status
    ---------
  • Has Study Datasets

    False

  • Has Specimens

    True

  • Specimen ID Type
    Coded
  • Study Website
  • The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

    False

  • Clinical Trial URLs
    N/A
  • Study type
    Epidemiology Study
  • Collection Type
    Open BioLINCC Study
  • Cohort type
    Adult
  • Interventions
  • Study Open Date (Data)

    None

  • Study Open Date (Specimens)

    2009-10-01

  • Date materials available

    2009-09-03

  • Last updated

    2023-02-07

  • Study period

    1974-1980

  • Study Contacts
  • NHLBI Division

    DBDR

  • Classification
    Transfusion Medicine
  • HIV study classification
    HIV-Related
  • COVID study classification
    non-COVID
  • Pre-Website # of Specimens Shipped

    13146

  • # of Returned Specimens

    0

  • Primary Publication URLs
    N/A
  • Conditions
    NANB Hepatitis
  • Objectives

    To establish a repository of specimens collected from prospectively identified cases of non-A, non-B (NANB) hepatitis after blood transfusion. The major intentions were to determine the incidence of that occurrence, identify the characteristics of the donors associated with the event, and have a resource available to compare laboratory donor screening methods during the study and in subsequent years following completion of the study.

  • Background

    From July 1974 through June 1980, the TTVS group prospectively identified cases of NANB hepatitis in a cohort of 1,533 transfused patients hospitalized short-term for various routine operative procedures. The TTVS collection has been used in a variety of studies, such as the evaluation and validation of Hepatitis C Virus (HCV) immunoassays in screening blood donors (1). In addition, specimens have been requested to evaluate poorly characterized hepatotropic viruses, transmissibility of new viruses (hepatitis G, HHV-8) by transfusion, and the dynamics of HBV/HCV viral replication and seroconversion in recipients.

  • Participants

    Serum specimens from 5,655 blood donors were collected from 4 participating blood centers distributed across the US. 3,121 patients were consented to participate in a study of viral hepatitis after blood transfusion. The majority of patients were scheduled for elective surgery. Of these subjects, 1,533 subsequently received blood transfusions. Both transfusion recipients and control subjects that did not require transfusion were observed and blood was collected prior to surgery or pre-transfusion and again during visits at 2-3 week intervals during the first 6 months following the transfusion episode and again between 8-10 months.


    A subset of this cohort was subsequently recruited into the Natural History Study of Non-A, Non-B Post Transfusion Hepatitis (NANB-TAH) that also has data and biospecimens available. Subjects cannot be linked between these two studies.

  • Design

    The collection originally consisted of aliquots of serum acquired at patient observation visits and from the collection agency for every donor to each TTVS recipient. These sera included the pre-transfusion or pre-surgical specimen, all interval blood draws from these patients and the non-transfused control patients, a specimen from the donor at the time of blood collection and in a subpopulation of donors a follow-up specimen from donors implicated in suspected cases of transfusion transmitted hepatitis and a matched set of non-implicated donors.

  • Conclusions

    The TTVS collection provides sera from a large transfusion donor-recipient study in which an untransfused control population with reasonably matched characteristics and of adequate size is available.

  • Disease classification
  • Publications

    1. Mosley JW, et al. (1990) Non-A, non-B hepatitis and antibody to hepatitis C virus. JAMA 263(1):77-78.

  • Mat types
    Plasma or Serum
    Serum
  • Network

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3.0 of the BioLINCC Handbook describes the components of the review process.

  • Material Types
  • General Freeze/Thaw Status
  • Visits (Vials)

    12/06/2018

     SerumPlasma or SerumTotal
    Recipient Visit 111,04699312,039
    Recipient Visit 26,255216,276
    Recipient Visit 312,4643312,497
    Recipient Visit 411,0948811,182
    Recipient Visit 57,0672967,363
    Recipient Visit 69,36977810,147
    Recipient Visit 75,8882036,091
    Recipient Visit 86,8812897,170
    Recipient Visit 99,1267009,826
    Recipient Visit 106,3502486,598
    Recipient Visit 117,2753097,584
    Recipient Visit 127,6015958,196
    Recipient Visit 133,9451704,115
    Recipient Visit 141,816511,867
    Recipient Visit 151,071281,099
    Recipient Visit 1676520785
    Recipient Visit 1767713690
    Recipient Visit 1855314567
    Recipient Visit 195098517
    Recipient Visit 204077414
    Recipient Visit 213293332
    Recipient Visit 222475252
    Recipient Visit 231930193
    Recipient Visit 241982200
    Recipient Visit 251561157
    Recipient Visit 2696096
    Recipient Visit 2784084
    Recipient Visit 2880080
    Recipient Visit 2980080
    Recipient Visit 3059059
    Recipient Visit 3160060
    Recipient Visit 3242042
    Recipient Visit 3330030
    Recipient Visit 3430030
    Recipient Visit 3528028
    Recipient Visit 3623023
    Recipient Visit 3721021
    Recipient Visit 3812012
    Recipient Visit 3926026
    Recipient Visit 4021021
    Recipient Visit 4113013
    Recipient Visit 4214014
    Recipient Visit 4318018
    Donor 112,3721,30213,674
    Donor 210,3301,03611,366
    Donor 36,7475997,346
    Donor 45,1884235,611
    Donor 53,7452974,042
    Donor 62,6962172,913
    Donor 71,8121471,959
    Donor 81,1781071,285
    Donor 980068868
    Donor 1048535520
    Donor 1135733390
    Donor 1222920249
    Donor 1312211133
    Donor 1469473
    Donor 1514317
    Donor 17101

     


    Last Modified: Sept. 4, 2025, 1:47 p.m.
  • Visits (Subjects)

    12/06/2018

     Serum
    Total number of subjectsAverage volume (ml) per subject
    Recipient Visit 11,5063.88
    Recipient Visit 21,5054.54
    Recipient Visit 31,5114.20
    Recipient Visit 41,5084.28
    Recipient Visit 51,5044.43
    Recipient Visit 61,5154.35
    Recipient Visit 71,5064.49
    Recipient Visit 81,5094.51
    Recipient Visit 91,4974.31
    Recipient Visit 101,4784.49
    Recipient Visit 111,4304.36
    Recipient Visit 121,3134.17
    Recipient Visit 131,0044.30
    Recipient Visit 143894.02
    Recipient Visit 152063.72
    Recipient Visit 161443.71
    Recipient Visit 171153.57
    Recipient Visit 18983.48
    Recipient Visit 19843.75
    Recipient Visit 20703.81
    Recipient Visit 21613.60
    Recipient Visit 22423.50
    Recipient Visit 23383.40
    Recipient Visit 24353.44
    Recipient Visit 25273.22
    Recipient Visit 26222.50
    Recipient Visit 27203.06
    Recipient Visit 28153.08
    Recipient Visit 29142.68
    Recipient Visit 30132.68
    Recipient Visit 31122.71
    Recipient Visit 3282.63
    Recipient Visit 3362.71
    Recipient Visit 3452.84
    Recipient Visit 3542.86
    Recipient Visit 3633.37
    Recipient Visit 3733.18
    Recipient Visit 3832.50
    Recipient Visit 3932.12
    Recipient Visit 4032.50
    Recipient Visit 4123.88
    Recipient Visit 4231.92
    Recipient Visit 4323.38
    Donor 11,5134.55
    Donor 21,2484.62
    Donor 38184.38
    Donor 46094.47
    Donor 54474.45
    Donor 63274.28
    Donor 72274.29
    Donor 81524.18
    Donor 91044.11
    Donor 10684.06
    Donor 11494.26
    Donor 12304.23
    Donor 13164.00
    Donor 14103.51
    Donor 1534.17
    Donor 1712.50
     Plasma or Serum
    Total number of subjectsAverage volume (ml) per subject
    Recipient Visit 19850.22
    Recipient Visit 2210.25
    Recipient Visit 3320.26
    Recipient Visit 4850.24
    Recipient Visit 52930.25
    Recipient Visit 67730.26
    Recipient Visit 72030.25
    Recipient Visit 82890.25
    Recipient Visit 96960.26
    Recipient Visit 102470.24
    Recipient Visit 113050.24
    Recipient Visit 125910.24
    Recipient Visit 131650.23
    Recipient Visit 14490.24
    Recipient Visit 15270.22
    Recipient Visit 16190.21
    Recipient Visit 17130.21
    Recipient Visit 18140.19
    Recipient Visit 1980.18
    Recipient Visit 2070.19
    Recipient Visit 2130.20
    Recipient Visit 2250.17
    Recipient Visit 2420.15
    Recipient Visit 2510.05
    Donor 19390.23
    Donor 27700.23
    Donor 34740.23
    Donor 43340.23
    Donor 52530.22
    Donor 61800.23
    Donor 71260.23
    Donor 8900.21
    Donor 9580.21
    Donor 10320.20
    Donor 11310.21
    Donor 12180.22
    Donor 13110.20
    Donor 1440.24
    Donor 1530.23


     


    Last Modified: Sept. 4, 2025, 1:47 p.m.