Retrovirus Epidemiology Donor Study (REDS): Special Repository Collections (SR) - Catalog
Retrovirus Epidemiology Donor Study (REDS): Special Repository Collections (SR)
HLB01921010a
REDS-SR
SPL
SRA
RED
False
False
True
Coded
False
Epidemiology Study
Open BioLINCC Study
---------
None
None
2010-05-05
2010-05-05
None
1990 - 2002
DBDR
Transfusion Medicine
HIV
---------
46250
0
Not Applicable (Specimens Only)
Not Applicable (Specimens Only)
No
Yes
Yes
Yes
Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.
Acquired Immunodeficiency Syndrome
Blood Donors
Blood Transfusion
HIV Infections
HIV-1
HIV-2
HTLV-I
HTLV-II
Retroviridae Infections
The objective REDS-I was to develop a major multicenter epidemiologic study of the human retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II in volunteer U.S. blood donors. Blood samples collected at the time of donation and/or in follow-up visits, were submitted to special repositories. Criteria for submission to these special repository collections were the status of HTLV and HIV testing.
REDS completed the collection of a large inventory of blood specimens from donors with specific test results for epidemiological and/or laboratory investigations of particular subpopulations of donors as the need arises. These eight special repositories (SRs) consist of specimens from donors who tested positive on routine screening assays, such as HTLV and HIV. Because of the unique linkage to demographic data and donation test results collected in the study database, investigations using these samples can be targeted to particular subsets of the blood donor population.
REDS blood centers that contributed to these repositories include:
- American Red Cross - Greater Chesapeake and Potomac Region, Baltimore, MD;
- American Red Cross - Southeastern Michigan Region, Detroit, MI;
- American Red Cross - Southern California Region, Los Angeles, CA;
- Blood Centers of the Pacific - San Francisco, CA; and
- Oklahoma Blood Institute - Oklahoma City, OK.
Kleinman S, Kaplan J, Khabbaz R, Calabro M, Thomson R, Busch M, and the REDS Study Group. Evaluation of a p21e-spiked Western blot (Immunblot) in confirming human T-cell lymphotropic virus type I or II infection in volunteer blood donors. J Clin Microbiol. 1994; 32: 603-607.
Busch M, Laycock M, Kleinman S, Wages J Jr, Kaplan J, Khabbaz R, Hollingsworth C, and the REDS Study Group. Accuracy of supplementary serologic testing for human T-lymphotropic virus types I and II in US blood donors. Blood. 1994;83:1143-1148.
Busch M, Kleinman S, Williams A, Smith J, Ownby H, Laycock M, Lee L, Pau C, Schreiber G. and the REDS Group. Frequency of human immunodeficiency virus (HIV) infection among contemporary anti-HIV-1 and anti-HIV-2 supplemental test-indeterminate blood donors. Transfusion. 1996;36:37-144.
Kleinman S, Busch M, Ownby H, Williams A, Gilcher R. HIV p24 antigen (Ag) indeterminate (Ind) donors are not infected with HIV (abstract). Transfusion. 1997; 37S:98S.
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
-
Material Types
-
General Freeze/Thaw Status
-
Visits (Vials)
Last Modified: Oct. 26, 2018, 9:58 a.m. -
Visits (Subjects)
10/26/2018
Serum Total number of subjects Average volume (ml) per subject 1 Visit per Subject 1,418 3.12 Plasma Total number of subjects Average volume (ml) per subject 1 Visit per Subject 19,534 7.22 No Visit Date 2,544 0.89 Whole Blood Total number of subjects Average volume (ml) per subject 1 Visit per Subject 15,560 4.26 Platelets Total number of subjects Average vials per subject 1 Visit per Subject 330 3.91 PBMC Total number of subjects Average vials per subject 1 Visit per Subject 2,930 5.49
Last Modified: Oct. 26, 2018, 9:58 a.m.